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The Organic Chemistry Of Biological Pathways

The Organic Chemistry Of Biological Pathways

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The authors (both of Cornell U.) provide a treatment of major biochemical pathways from the perspective of mechanistic organic chemistry, focusing on the reactivity patterns of the substrate molecules and on the organic, arrow-pushing details of the individual reactions. After the presentation of introductory material on classes of small biological molecules, common organic mechanisms, stereochemistry, and prochirality, the text examines the metabolism of lipids, carbohydrates, amino acids, and nucleotides. Each chapter discusses the chemistry of degradative metabolism, biosynthetic reactions for creating small molecules, and the sequential chemical transformations of the metabolic pathways. Also included is an additional chapter on the biosynthesis of major classes of natural products such as eicosanoids, morphine, and tetrapyrroles, among others. Annotation c2005 Book News, Inc., Portland, OR (booknews.com)

作者簡介

John E. McMurry received his B.A. from Harvard University and his Ph.D. at Columbia University. Dr. McMurry is a Fellow of the American Association for the Advancement of Science, and an Alfred P. Sloan Research Foundation Fellow. He has received several awards, which include the National Institutes of Health Career Development Award, the Alexander von Humboldt Senior Scientist Award, and the Max Planck Research Award. In addition to The Organic Chemistry of Biological Pathways, he is also the author of Organic Chemistry, Fundamentals of Organic Chemistry, and Chemistry (with Robert Fay).

Tadhg P. Begley received his B.Sc. from National University of Ireland and his Ph.D. at the California Institute of Technology. Dr. Begley is the recipient of many awards, including the Merck Faculty Development Award and the Camille and Henry Dreyfus Teacher-Scholar Award. His research group uses the principles and techniques of organic chemistry to study complex organic transformations found in vitamin biosynthetic pathways. In addition to The Organic Chemistry of Biological Pathways, Dr. Begley has edited Cofactor Biosynthesis: A Mechanistic Perspective.

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