Recent Advances in Cancer Research and Therapy

Liu (Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, and Xinyuan Institute of Medicine and Biotechnology, Zhejiang Sci-Tech U., China) et al. compile 21 articles on recent advances in cancer research and therapy, contributed by researchers working in China, the US, and UK in molecular cell biology, molecular oncology, biological chemistry, cancer research, pharmacology, surgery, and other areas. They discuss progress in China in cancer biotherapy and chemotherapeutic drug research; cancer targeting gene-viro-therapy; the relationship between antiproliferative activities and class I MHC surface expression of mouse interferon proteins on B16-F10 melanoma cells; mitotic regulator Hec1 as a potential target for cancer therapy; advances in liposome-based targeted gene therapy; rewiring the intracellular signaling network in cancer; and the research and development of highly potent antibody-based drug conjugates and fusion proteins for cancer therapy. Also covered are cancer stem cells; the p53 tumor antigen as a therapy target and biomarker; the recombinant adenoviral-p53 agent; a three-dimensional tumor model and T-lymphocytes immunotherapy; doxorubicin cardiotoxicity; the biochemistry and pharmacology of human ABCC1/MRP1; the role of traditional Chinese medicine; the effect of arsenic trioxide on acute promyelocytic leukemia and glioma; nasopharyngeal and esophageal carcinoma; colorectal cancer in China; and molecular and cellular characteristics of small cell lung cancer. There is no index. Annotation c2012 Book News, Inc., Portland, OR (booknews.com)