Applied Rnai ― From Fundamental Research to Therapeutic Applications

In 12 chapters, genetics, molecular biomedicine, and other researchers from around the world detail advances in basic applied RNA interference (RNAi) medical research and applications in RNAi-based therapies. They discuss biogenesis and applications of microRNA; non-canonical microRNA biogenesis and function; non-coding RNAs and the epigenetic control of gene expression; the clinical translation of microRNA technologies for somatic cell reprogramming; systems biology tools for understanding the role of host microRNAs in infection, particularly in HIV; synthetic microRNA blocking agents; using microRNAs to regulate transgene expression, for gene silencing, and using RNAi for the treatment of viral infections; the role of microRNAs in cancers associated with human tumor viruses; microRNAs as cancer biomarkers; and microRNA deregulation in trinucleotide repeat expansion disorders. Distributed in the US by ISBS. Annotation c2014 Ringgold, Inc., Portland, OR (protoview.com)