苯乙烯(Styrene)為工業上廣泛使用的化學物質並且是已知的致神經毒性物質。人類暴露於苯乙烯環境下將導致神經系統的慢性疾病，像是導致反應時間變長和對顏色辨識的混淆等。苯乙烯在體內會進一步代謝成苯乙烯氧化物(Styrene oxide; S O)，此物質為致突變劑與致癌物質。在過去的研究中對苯乙烯物質相關的毒理機制還不甚清楚。因此，本研究目的是利用微陣列基因晶片技術探討造船廠工人暴露於苯乙烯物質環境下對其整體基因表現之影響。本研究一共募集到19人其中暴露組有11人包含抽菸者6人與非抽菸者5人及非暴露組8人，個人樣品(含空氣樣品及血液樣品)於當天工作前後收集並且進一步分離血液中的RNA進行微陣列基因晶片分析。晶片分析的結果利用gene ontology tree machine (GOTM)軟體進行表現基因之歸納分析。根據GOTM的分析結果發現暴露組工人相較於非暴露組工人其相關於神經系統發育、胚胎發育、細胞訊息傳遞和視覺認知等基因表現皆受到抑制，因此將影響這些機制之功能。本研究為第一個針對暴露於苯乙烯物質之工人進行整體基因表現之探討並且確認人體經苯乙烯物質暴露後將影響其視覺認知功能。另外，在流行病學之研究中，a. 尿液中苯乙烯代謝物和氧化傷害指標8-OHdG之分析部分，無論是在直接接觸之工作者或者在高濃度苯乙烯暴露者尿液中代謝物MA及PGA均有顯著較高的值(p
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Piano PersonalityThis incredible new comprehensive resource presents over 150 pieces by J. S. Bach in lead sheet format. It includes instrumental music from concertos, fantasias, fugues, inventions, p
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The ICMS Workshop on Geometric and Combinatorial Methods in Group Theory, held at Heriot-Watt University in 1993, brought together some of the leading research workers in the subject. Some of the survey articles and contributed papers presented at the meeting are collected in this volume. The former cover a number of areas of current interest and include papers by: S. M. Gersten, R. I. Grigorchuk, P. H. Kropholler, A. Lubotzky, A. A. Razborov and E. Zelmanov. The contributed articles, all refereed, range over a wide number of topics in combinatorial and geometric group theory and related topics. The volume represents a summary of the state of knowledge of the field, and as such will be indispensable to all research workers in the area.
Seismology has complementary observational and theoretical components, and a thorough understanding of the observations requires a sound theoretical background. This book bridges the gap between introductory textbooks and advanced monographs by providing the necessary mathematical tools and demonstrating how to apply them. Each seismological problem is carefully formulated and its solution is derived in a step-by-step approach. The text includes student exercises (with hints), for which solutions are available on a dedicated website. This website also contains numerous downloadable programs for the computation of reflection and transmission coefficients, for the generation of P and S wave radiation patterns and synthetic seismograms, in infinite media. This book will therefore find a receptive audience among advanced undergraduate and graduate students interested in developing a solid mathematical background to tackle more advanced topics in seismology. It will also form a useful refer
On the heels of the successful P.S. I Hate it Here comes an all-new, even more outrageous and laugh-out-loud funny collection of real letters written by children ages eight to sixteen to their parents
A story that began in the first issue of Hellboy concludes with the B.P.R.D. team set to permanently wipe out the subterranean colony of frog monsters. The team tracks down Memnan Saa's hideout, but s
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