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ODE/PDE alpha-Synuclein Models for Parkinson’s Disease discusses a mechanism for the evolution of Parkinson’s Disease (PD) based on the dynamics of the protein alpha-synuclein, a monomer that has been

Mathematical modelling of physical and chemical systems is used extensively throughout science, engineering, and applied mathematics. To use mathematical models, one needs solutions to the model equations; this generally requires numerical methods. This book presents numerical methods and associated computer code in Matlab for the solution of a spectrum of models expressed as partial differential equations (PDEs). The authors focus on the method of lines (MOL), a well-established procedure for all major classes of PDEs, where the boundary value partial derivatives are approximated algebraically by finite differences. This reduces the PDEs to ordinary differential equations (ODEs) and makes the computer code easy to understand, implement, and modify. Also, the ODEs (via MOL) can be combined with any other ODEs that are part of the model (so that MOL naturally accommodates ODE/PDE models). This book uniquely includes a detailed line-by-line discussion of computer code related to the ass

Aimed at graduates and researchers, and requiring only a basic knowledge of multi-variable calculus, this introduction to computer-based partial differential equation (PDE) modeling provides readers with the practical methods necessary to develop and use PDE mathematical models in biomedical engineering. Taking an applied approach, rather than using abstract mathematics, the reader is instructed through six biomedical example applications, each example characterized by step-by-step discussions of established numerical methods and implemented in reliable computer routines. Adopting this technique, the reader will understand how PDE models are formulated, implemented and tested. Supported by a set of rigorously tested general purpose PDE routines online, and with enhanced understanding through animations, this book will be ideal for anyone faced with interpreting large experimental data sets that need to be analyzed with PDE models in biomedical engineering.