Chemoprevention Of Cancer And Dna Damage By Dietary Factors

This reference work provides a comprehensive overview of the field of dietary chemoprevention of cancer. It reviews the wide variety of dietary factors and mechanisms of anticarcinogenesis and antimutagenesis that have been identified in vitro and in animal and human studies. This volume covers the most recent molecular mechanism by which dietary antimutagens and anticarcinogens function, and also notes the needs for further research in this potentially important area of public health. It is a must-have reference for nutritional scientists, medicinal chemists, food scientists, biotechnologists, pharmacists, and molecular biologists working in academia or the pharmaceutical and food industries, as well as governmental and regulatory agencies concerned with nutrition and cancer.
With a foreword by Bruce N. Ames.
Sections of the book:
● General Principles
● Experimental Models and Methods Used in Chemoprevention
● Selected Chemoprotective Dietary Factors and Components

Siegfried Knasmüller is head of the Environmental Toxicology Group at the Institute of Cancer Research, Medical University of Vienna. He obtained his academic degrees from Vienna University and continued his studies in the fields of genetic toxicology and cancer research at the University of Leiden, at the Case Western Reserve University, at US EPA in North Carolina and at the Institute of Experimental Cancer Research in Innsbruck before taking up his present appointment. Siegfried Knasmüller authored over 160 scientific publications and organized several international conferences. He is member of the editoral board of a number of scientific journals was involved in a number of EU research projects.
David M. DeMarini is a genetic toxicologist at the U.S. Environmental Protection Agency, Research Triangle Park, North Carolina. He received all of his academic degrees from Illinois State University, Normal, Illinois, and he did further studies at the Oak Ridge National Laboratory, Tennessee, and at the National Toxicology Program, NIH/NIEHS, Research Triangle Park, North Carolina. He is the past-president of the Environmental Mutagen Society and of the International Association of Environmental Mutagen Societies. David M. DeMarini is editor and editorial board member of numerous journals, as well as an Adjunct Professor in the Gillings School of Global Public Health, University of North Carolina at Chapel Hill. He has more than 150 scientific publications in the field of mutagenesis.
Ian Johnson leads the gastrointestinal cancer prevention team at the Institute of Food Research (IFR), Norwich, UK, and his research interests include human nutrition, colorectal cancer prevention and intestinal epithelial epigenetics. Ian Johnson graduated from London University and Aston University, and undertook post-doctoral research in London and York before joining IFR in 1979. He holds honorary chairs in the Schools of Medicine and Biological Sciences at the University of East Anglia.
Clarissa Gerhäuser is heading the Cancer Chemoprevention Group at the German Cancer Research Center in Heidelberg. She studied Pharmacy at the University of Würzburg and obtained a Ph.D. in pharmaceutical biology at the Ludwig Maximilians University of Munich. She then worked as a research assistant professor in the area of cancer chemoprevention at the University of Illinois at Chicago before taking up the present appointment. Her research interest is in the field of novel plant- or diet-derived chemopreventive compounds and synthetic analogs. Clarissa Gerhäuser has authored more than 70 research articles, reviews and book chapters on cancer chemopreventive agents.

INTRODUCTION.
HISTORICAL BACKGROUND.
GENERAL PRINCIPLES.
Molecular Mechanisms of Cancer Formation.
Consequences of DNA Damage.
The Role of Nutrition in the Etiology of Human Cancer.
Mechanisms of Antimutagenesis and Anticarcinogenesis (Overview).
Induction of DNA Damage and Cancer by Food Components.
Interaction of Dietary Factors with Drug Metabolising Enzymes.
Regulation of Drug Metabolising and Antioxidant Enzymes.
Interaction of Dietary Factors with Cell Signalling and Cell Division.
Hormones and Cancer.
DNA Methylation.
Prevention of Angiogenesis and Metastasis.
Role of Oxidants and Antioxidants.
EXPERIMENTAL MODELS AND METHODS USED IN CHEMOPREVENTION STUDIES.
Experiments Concerning the Prevention of DNA damage.
Preneoplastic Foci Models and Long Term Carcinogenicity Studies with Rodents.
Methods Used to Study Alterations of Cell Signalling and Proliferation.
Measurement of Drug Metabolising Enzymes.
Detection of Dietary Antioxidants.
Genomics and Proteomics.
Design of Epidemiological Studies.
SELECTED CHEMOPREVENTIVE DIETARY FACTORS AND COMPONENTS.
Carotenoids and Vitamin A.
Vitamins D, C, E.
Folate and Vitamins B6 and B12.
Phytosterins.
Saponins (should we include this chapter).
Glucosinolates and Cruciferous Vegetables.
Selected Flavonoids.
Selected Phenolic Compounds.
Sulfides in Allium Vegetables.
Chlorphylls.
Dietary Fibers.
Non Starch Polysaccharides and their Degradation Products.
Fatty acids (should we include this chapter).
Coffee and its Constituents.
Teas.
Green Tea and its Constituents.
Chung.
Other teas.
Protective Components of Alcoholic Beverages.
Wine.
Beer.
Selected Spices and their ingredients.
Protease Inhibitors.
Phytoestrogens.
Lignans in Cereals.
Isoflavones in Soy.
Lactobacilli and Fermented Foods.
Micronutrients (Zinc, Selenium, ect).