Case Studies in Immunology：A Clinical Companion

Case Studies in Immunology, Sixth Edition, presents major topics of immunology through a selection of clinical cases that reinforce and extend the basic science. The case histories illustrate essential points about the mechanisms of immunity and describe immunological problems seen in the clinic. This new edition vividly illustrates the importance of an understanding of immunology in diagnosis and therapy. Case Studies in Immunology highlights major common disorders of immunity, including hypersensitivity types I-IV, immune deficiencies, and autoimmune disorders. Each case history is preceded by basic scientific facts essential to understanding the immunology behind the specific disorders. An end-of-case summary, questions, and discussion points conclude each case.
Case Studies in Immunology can be used as a stand-alone book, or as a clinical companion alongside Janeway’s Immunobiology, Eighth Edition. A marginal icon in Janeway’s Immunobiology provides the reader with a link to the relevant Case Study, where the science is applied in a clinical setting.

The book includes a total of 53 cases. The Sixth Edition is extensively revised and updated and includes ten new cases:

DiGeorge Syndrome
Hemophagocytic Lymphohistiocytosis
Chediak-Higashi Syndrome
Hyper IgE Syndrome
Ataxia Telangiectasia
Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome
Severe Congenital Neutropenia
Recurrent Herpes Simplex Encephalitis
Systemic Onset Juvenile Idiopathic Arthritis
Crohn’s Disease

Case 1 X-linked AgammaglobulinemiaCase 2 CD40 Ligand DeficiencyCase 3 Activation-induced Cytidine Deaminase DeficiencyCase 4 Common Variable ImmunodeficiencyCase 5 X-linked Severe Combined ImmunodeficiencyCase 6 Adenosine Deaminase DeficiencyCase 7 Omenn SyndromeCase 8 MHC Class II DeficiencyCase 9 DiGeorge SyndromeCase 10 Acquired Immune Deficiency Syndrome (AIDS)Case 11 Graft-Versus-Host DiseaseCase 12 MHC Class I DeficiencyCase 13 X-linked Lymphoproliferative SyndromeCase 14 Hemophagocytic LymphohistiocytosisCase 15 Chediak-Higashi SyndromeCase 16 Wiskott-Aldrich SyndromeCase 17 Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal DystrophyCase 18 Immune Dysregulation, Polyendocrinopathy, Enteropathy X-linked DiseaseCase 19 Autoimmune Lymphoproliferative Syndrome (ALPS)Case 20 Hyper IgE SyndromeCase 21 Ataxia Telangiectasia Case 22 Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) SyndromeCase 23 X-linked Hypohidrotic Ectodermal Dysplasia and ImmunodeficiencyCase 24 Interferon-γ Receptor DeficiencyCase 25 Severe Congenital NeutropeniaCase 26 Chronic Granulomatous DiseaseCase 27 Leukocyte Adhesion DeficiencyCase 28 Recurrent Herpes Simplex EncephalitisCase 29 Interleukin 1 Receptor-associated Kinase 4 DeficiencyCase 30 Congenital AspleniaCase 31 Hereditary AngioedemaCase 32 Factor I DeficiencyCase 33 Deficiency of the C8 Complement ComponentCase 34 Hereditary Periodic Fever SyndromesCase 35 Systemic Onset Juvenile Idiopathic ArthritisCase 36 Rheumatoid ArthritisCase 37 Systemic Lupus ErythematosusCase 38 Mixed Essential CryoglobulinemiaCase 39 Crohn’s DiseaseCase 40 Multiple SclerosisCase 41 Autoimmune Hemolytic AnemiaCase 42 Myasthenia GravisCase 43 Pemphigus VulgarisCase 44 Celiac DiseaseCase 45 Acute Infectious MononucleosisCase 46 Hemolytic Disease of the NewbornCase 47 Toxic Shock SyndromeCase 48 Lepromatous LeprosyCase 49 Acute Systemic AnaphylaxisCase 50 Allergic AsthmaCase 51 Atopic DermatitisCase 52 Drug-induced Serum SicknessCase 53 Contact Sensitivity to Poison Ivy
Answers
Figure Acknowledgments
Index