Mitochondrial Medicine: Volume 1: Targeting Mitochondria

1. Using QSAR Models to Predict Mitochondrial Targeting by Small Molecule Xenobiotics within Living Cells

Richard W. Horobin

2. DQAsomes as the Prototype of Mitochondria-targeted Pharmaceutical Nanocarriers: An Update

Volkmar Weissig, Maria Lozoya, Nusem Yu, and Gerard G.M. D'Souza

3. Synthesis and Characterization of Mitochondria-Targeted Triphenyltriphenylphosphonium Bolaamphiphiles

Francesca Ceccacci, Simona Sennato, Edoardo Rossi, Raffaele Proroga, Stefano Sarti, Marco Diociaiuti, Stefano Casciardi, Valentina Mussi, Alessia Ciogli, Federico Bordi, Giovanna Mancini, and Cecilia Bombelli

4. Synthesis and Evaluation of ¹⁸F-labeled Fluoroalkyl Triphenylphosphonium Salts as Mitochondrial Voltage Sensors in PET Myocardial Imaging

Dong-Yeon Kim and Jung-Joon Min

5. Novel Mitochondria-Targeted Triphenylphosphonium Conjugates of Linear beta-Phosphorylated Nitrones: Preparation, ³¹P NMR Mitochondrial Distribution, EPR Spin Trapping Reporting, and Site-Directed Anti-Apoptotic Properties

Consuelo Petrocchi, Sophie Th彋iot-Laurent, Marcel Culcasi, and Sylvia Pietri

6. Insights on Targeting Small Molecules to the Mitochondrial Matrix and the Preparation of MitoB and MitoP as exomarkers of Mitochondrial Hydrogen Peroxide

Andrew G. Cairns, Stephen J. McQuaker, Michael P. Murphy, and Richard C. Hartley

7. Synthesis of Triphenylphosphonium Phospholipid Conjugates for the Preparation of Mitochondriotropic Liposomes

Parul Benien, Mohammed Almuteri, Shrey Shah, Mark B鐬lke, Ahmed Mehanna, and Gerard G. M. D'Souza

8. Imaging Mitochondrial Hydrogen Peroxide in Living Cells

Alexander R. Lippert, Bryan C. Dickinson, and Elizabeth J. New

9. Synthesis and Testing Of Novel Isomeric Mitochondriotropic Derivatives of Resveratrol and Quercetin

Lucia Biasutto, Andrea Mattarei, and Cristina Paradisi

10. Bridging the Gap between Nature and Antioxidant Setbacks: Delivering Gallic Acid to Mitochondria

Fernando Cagide, Catarina Oliveira, Jos?Teixeira, Paulo J. Oliveira, and Fernanda Borges

11. Liposomal Delivery of Cyclocreatine Impairs Cancer Cell Bioenergetics Mediating Apoptosis

Samayita Ganguly and Tamer Elbayoumi

12. Mt-fura-2, a ratiometric Mitochondria-targeted Ca²⁺ sensor. Determination of spectroscopic properties and Ca²⁺ Imaging Assays

Andrea De Nadai, Nicola Vajente, Diana Pendin, and Andrea Mattarei

13. Sequence-Specific Control of Mitochondrial Gene Transcription using Programmable Synthetic Gene Switches called MITO-PIPs

Takuya Hidaka, Hiroshi Sugiyama, and Ganesh N. Pandian

14. Targeting the Mitochondrial Genome via a MITO-Porter: Evaluation of mtDNA and mtRNA Levels and Mitochondrial Function

Yuma Yamada and Hideyoshi Harashima

15. mTRIP, an Imaging Tool to Investigate Mitochondrial DNA dynamics in Physiology and Disease at the Single-Cell Resolution

Laurent Chatre and Miria Ricchetti

16. Development of Mitochondria-Targeted Imaging Nanoplatforms by Incorporation of Fluorescent Carbon Quantum Dots

Ye Zhang and Hong Bi

17. Norbormide-based Probes and their Application for Mitochondrial Imaging in Drosophila Melanogaster

Alessia Forgiarini, Zifei Wang, Sergio Bova, Margaret Anne Brimble, Brian Hopkins ³, David Rennison, and Genny Orso

18. Live-cell Assessment of Reactive Oxygen Species Levels Using Dihydroethidine

Sander Grefte and Werner J.H. Koopman