This is a collection of portraits of twelve outstanding women who lived and worked in Cambridge during the century before women were admitted fully to membership of the University. The subjects include Jane Harrison, distinguished scholar of Greek religion, Mrs Sidgwick, founder of Newnham College, Eileen Power, medieval historian, Nora Chadwick, scholar of Norse and Celtic, Honor Fell, cell biologist and founding force behind the Strangeways Laboratory, Frances Cornford, poet, and Rosalind Franklin, whose work on DNA was essential to the Watson-Crick model. All were outstanding personalities as well as distinguished scholars, and the 'twelve portraits' give a vivid account of their lives and work.
Considerable attention is being paid to the use of molecular evidence in studies of human diversity and origins. Much of the early work was based on evidence from mitochondrial DNA, but this has been supplemented by important information from nuclear DNA from both the Y chromosomes and the autosomes. The bulk of the material available is also from living populations, but this is being extended by the study of DNA from archaic populations. The underlying models used in interpreting this evidence are developments of the neutral theory of molecular evolution, but also consider the possible role of selection. This 1996 volume brings together evidence from an international group of research workers. It will be an important reference for researchers in human biology, molecular biology and genetics alike.
Considerable attention is being paid to the use of molecular evidence in studies of human diversity and origins. Much of the early work was based on evidence from mitochondrial DNA, but this has been supplemented by important information from nuclear DNA from both the Y chromosomes and the autosomes. The bulk of the material available is also from living populations, but this is being extended by the study of DNA from archaic populations. The underlying models used in interpreting this evidence are developments of the neutral theory of molecular evolution, but also consider the possible role of selection. This 1996 volume brings together evidence from an international group of research workers. It will be an important reference for researchers in human biology, molecular biology and genetics alike.
From Nobel Prize-winning scientist James D. Watson, a living legend for his work unlocking the structure of DNA, comes this candid and entertaining memoir, filled with practical advice for those start
The book brings together papers covering the most recent scientific research from the top endophyte researchers in the world. It presents the state of the art in our knowledge and technical capacity and explores future directions of this work. It is highly relevant and timely because of the need to improve global food security and its sustainability, and also to provide novel bioactive molecules for medicine. There is also a need to protect forestry in a changing and growing world. Endophytes offer a huge potential to reduce environmentally damaging agricultural inputs such as fertilisers and pesticides. They are also a largely overlooked group of organisms where much basic science remains to be undertaken. For example, new molecular tools of DNA profiling using high throughput environmental sequencing are allowing the exploration of a previously largely unknown resource. There is a pressing need to convert scientific research on endophytes into practical application. This book describ
Integer linear programming (ILP) is a versatile modeling and optimization technique that is increasingly used in non-traditional ways in biology, with the potential to transform biological computation. However, few biologists know about it. This how-to and why-do text introduces ILP through the lens of computational and systems biology. It uses in-depth examples from genomics, phylogenetics, RNA, protein folding, network analysis, cancer, ecology, co-evolution, DNA sequencing, sequence analysis, pedigree and sibling inference, haplotyping, and more, to establish the power of ILP. This book aims to teach the logic of modeling and solving problems with ILP, and to teach the practical 'work flow' involved in using ILP in biology. Written for a wide audience, with no biological or computational prerequisites, this book is appropriate for entry-level and advanced courses aimed at biological and computational students, and as a source for specialists. Numerous exercises and accompanying soft
Considered 'the father of genomics', Fred Sanger (1918–2013) paved the way for the modern revolution in our understanding of biology. His pioneering methods for sequencing proteins, RNA and, eventually, DNA earned him two Nobel Prizes. He remains one of only four scientists (and the only British scientist) ever to have achieved that distinction. In this, the first full biography of Fred Sanger to be published, Brownlee traces Sanger's life from his birth in rural Gloucestershire to his retirement in 1983 from the Medical Research Council's Laboratory of Molecular Biology in Cambridge. Along the way, he highlights the remarkable extent of Sanger's scientific achievements and provides a real portrait of the modest man behind them. Including an extensive transcript of a rare interview of Sanger by the author, this biography also considers the wider legacy of Sanger's work, including his impact on the Human Genome Project and beyond.
