Modern Biooxidation - Enzymes, Reactions And Applications

Filling a gap in the literature, leading expert editors and top international authors present the field of biooxidation from an academic and industrial point of view, taking many examples from modern pharmaceutical research. Topics range from the application of different monooxygenases to applications in the pharmaceutical industry, making this volume of high interest not only for those working in biotechnology but also for organic synthetic chemists, among others.

Rolf Schmid obtained his PhD in 1970. After post-doctoral studies in France and the USA, he joined the research laboratories of Henkel KGaA in D�sseldorf in 1972 where he became Director of the Biotechnology Laboratories. In 1987, he moved to the 'Gesellschaft f�r Biotechnologische Forschung' (GBF) in Braunschweig where he headed the Division of Enzyme Technology and Natural Products Research.
In 1993, he accepted an invitation to build up the newly founded Institute for Technical Biochemistry at the University of Stuttgart. He is further in charge of the Department of Molecular Biotechnology at the Fraunhofer Institute for Membrane Science and Biotechnology in Stuttgart, and he is chairman of the IUPAC Commission of Biotechnology.

Vlada Urlacher is a young researcher and is the head of the Biocatalysis Group at the Institute for Technical Biochemistry at the University of Stuttgart.

"This book should be of value to those interested in developing such processes." (Journal of Medicinal Chemistry, Volume 51, Number 10)

1. INTRODUCTION AND HISTORY
2. BIOOXIDATION FOR MEDICAL AND PHARMACEUTICAL RESEARCH
2.1 Preparation of Drug Metabolites Using Fungal and Bacterial Strains
2.2 Liver Monooxygenases
2.3 Recombinant Human Liver Monooxygenases in Pharmacological Research
2.4 Human Cytochrome P450 Monooxygenases -
A General Model of Substrate Specificity and Regioselectivity
2.5 Steroid Oxidation
3. BIOOXIDATION FOR BIOCATALYSIS AND ORGANIC SYNTHESIS
3.1 Selective Microbial Oxidations in Industry
3.2 PQQ- and FAD-Dependant Oxidases
3.3 Laccases and their Applications
3.4 Dioxygenases and their Applications
3.5 Heme Monooxygenases: A Superfamily, their Substates and their Applications
3.6 Electroenzymologie with Monooxygenases: Challenges, Perspectives and Practical Considerations
3.7 Baeyer-Villiger Monooyxgenases
3.8 Heme Monooxygenases: The Reductase Issue
3.9 A Modular Approach to Biotransformation Using Microbial Cytochromes
4. PLANT MONOOXYGENASES AND THEIR APPLICATIONS
5. COFACTOR REGENERATION
6. BIOOXIDATION IN INDUSTRY