GABAb Receptor Pharmacology: A Tribute to Norman Bowery

This monograph was assembled to honor Professor Norman Bowery and his work on the 30th anniversary of his discovery of the GABA receptor. In the present volume leading neuroscientists from academia and industry provide a perspective of current research, both basic and translational in the discovery of drugs acting at the GABA receptor. While it is impossible to include reports from all who have contributed significantly to characterizing this receptor the topics covered provide a comprehensive review of the field and the current state of research in this area. Included are chapters on the chemistry of GABA agonists and antagonists, on the genetics and molecular composition of the site, its regulation and trafficking, and its role in controlling cellular, autonomic, and behavioral function. There are also chapters describing the potential clinical utility of drugs regulating GABA activity receptor, in the areas of hypertension, gastroesophageal reflux disease. Down syndrome, depression, and substance abuse.

The information contained in this text will be of particular interest to neuroscientists in general and to neuropharmacologists in particular.