Drug Stereochemistry: Analytical Methods and Pharmacology

"Updated to reflect modern advances in the techniques and methodology of drug stereochemistry, the Third Edition comprehensively presents all aspects of chiral drugs from scientific, academic, governmental, industrial, and clinical points of view. This stand-alone text covers the lifespan of stereochemistry, from its early history, including an overview of terms and concepts, to the current drug development process, legal and regulatory issues, and the new stereoisomeric drugs. New topics in the Third Edition include: The use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug discovery; How stereochemistry impacts decisions made in the Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) stages of drugdiscovery; A chapter on pharmacokinetics and pharmacodynamics that discusses the issues faced during the final stages of the drug development process; The impact of International Conference on Harmonisation on the use of single isomer drugs; Racemic switches; The concept of molecular chiral recognition and how it affects the separation and behavior of stereochemically pure drugs; A chapter on the legal perspectives of patent issues surrounding racemic switches and the marketing of single enantiomer switches"--Provided by publisher.

Professor Krzysztof Jozwiak is head of laboratory of medicinal chemistry and neuroengineering of Medical University of Lublin, Poland

Dr W John Lough is reader in pharmaceutical analysis in the Department of Pharmacy, Health and Well-Being at the University of Sunderland, UK

Irving W. Wainer, Ph.D. is senior investigator, in the Bioanalytical Chemistry and Drug Discovery Section, Laboratory for Clinical Investigation, National Institute of Aging/National Institutes of Health