Autoimmunity: Physiology And Disease

Presents a coherent view of autoreactivity in health and disease and considers potential new approaches to the therapy of autoimmune diseases. This volume is a vital source of information for clinicians, researchers, faculty, and students in microbiology, immunology and pathology.

Antonio Manuel Pinto Amaral Coutinho is a Portuguese immunologist, and as of 2010 the only Portuguese ISI highly cited researcher. He has been Director of the Instituto Gulbenkian de Ciencia since 1998. Michel Kazatchkine is a French physician, diplomat and advocate, best known for his work in international AIDS treatment issues. From February 2007 to March 2012 he was director of The Global Fund to Fight AIDS, Tuberculosis and Malaria.

Partial table of contents:

PHYSIOLOGICAL AUTOREACTIVITY.

Autoimmunity Today (A. Coutinho & M. Kazatchkine).

Light Chain Variable Region Gene Repertoire in Human Autoantibodies (K. Victor & J. Capra).

Stimulation of T and B Cells (J. Andersson, et al.).

Lymphocyte Population Kinetics: A Cellular Competition Model (A. Freitas & B. Rocha).

Tolerance and Autoimmunity in the Peripheral T-Cell Repertoire (J. Miller).

Autoimmunity and Idiotypic Networks (J. Stewart).

AUTOIMMUNE DISEASE.

Boundaries Between Physiological Autoreactivity and Pathological Autoimmunity (M. Kazatchkine & A. Coutinho).

Immunological Disturbances Responsible for Graves' Disease (J. Dwyer).

Is Experimental Allergic Encephalomyelitis a Model of Multiple Sclerosis?

(E. Heber-Katz).

Immunodeficiency and Autoimmunity (F. Rosen).

Autoimmunity Tomorrow (A. Coutinho & M. Kazatchkine).

Index.