LANTHANIDE SHIFT REAGENTS FOR STEREOCHEMICAL ANALYSIS

The use of lanthanide shift reagents (LSR) in NMR spectroscopy has tremendously increased over the past 15 years. Today textbooks as well as laboratory manuals describe the applications of LSR to chemical structure analysis. For the use of lanthanide shift reagents in stereochemical analysis, however, this book provides the first comprehensive review. It illustrates their application in the determination of the configuration of organic compounds which is a proving ground for the refinement of LSR theory. In five chapters the authors discuss computer-aided approaches to elucidating the geometry of LSR-substrate complexes, show solutions of complex stereochemical problems and present the new and successful reagent class of Ag(I)/Ln(III) diketonate complexes. Stereochemical analyses of diastereotopic groups, ring conformations, bridged polycylic compounds and deuterium labeling are further keywords which prove that this book offers an up-to-date account of an active area of research.

An introduction to Lanthanide Shift Reagents (T. Morrill).

Computer Approaches to the Geometry of the LSR-Substrate Complex: Geometry of Shift Reagents-Substrate Complexes, Simulation of Induced Chemical Shifts (J. Chiasson & K. Jankowski).

The Nature of the LSR-Substrate Complex (D. Raber).

Solutions to Stereochemical Problems (J. Paasivirta).

Binuclear Lanthanide(III)-Silver(I) NMR Shift Reagents (T. Wenzel).

Indexes.