Medicinal Chemistry Of Nucleic Acids
商品資訊
系列名：Wiley Series in Drug Discovery and Development
ISBN13：9780470596685
出版社：John Wiley & Sons Inc
作者：Zhang
出版日：2011/08/11
裝訂／頁數：精裝／464頁
規格：24.1cm*15.9cm*2.5cm (高/寬/厚)
版次：1
商品簡介
作者簡介
ZHEN XI, PhD, is Deputy Director of the State Key Laboratory of Elemento-organic Chemistry, as well as Professor of Pesticide Science and Chemical Biology, and Vice Dean of the College of Chemistry at Nankai University. He holds seven patents and has written a number of reviews and book chapters and sixty-four original research articles.
JYOTI CHATTOPADHYAYA, PhD, DSc, is the University Chair of Bioorganic Chemistry and the chair of the Chemical Biology Program at Uppsala University. He is a guest professor of chemistry at both Jilin University and Nankai University. He has written over 410 peer-reviewed original research articles and is also on the editorial boards of several international journals.
目次
Introduction (L.H.Zhang, Z.Xi, and J. Chattopadhyaya).
Contributors.
Chapter 1 Recent Advances in Carbocyclic Nucleosides: Synthesis and Biological Activity (Jianing Wang, Ravindra K. Rawal, and Chung K. Chu).
Chapter 2 Structures and Functions of Nucleic Acids Modified with S, Se and Teand Complexed with Small Molecules (Wen Zhang, Jia Sheng, and Zhen Huang).
Chapter 3 Unraveling of the NAD Cyclizing and Calcium Signaling Functions of Human CD38 (Hon Cheung Lee).
Chapter 4 DNA and RNA binding small molecules (Shibo Li and Zhen Xi).
Chapter 5 G-quadruplex DNA and its ligands in anticancer therapy (Zhi-Shu Huang , Jia-Heng Tan, Tian-Miao Ou, Ding Li, and Lian-Quan Gu).
Chapter 6 Molecular modeling in nucleic acid targeted drug design (Lidan Sun, Hongwei Jin, Liangren Zhang, and Lihe Zhang).
Chapter 7 Structure Of 10-23 DNAzyme In Complex With The Target RNA in silico – A Progress Report On The Mechanism of RNA Cleavage by DNA enzyme (Oleksandr Plashkevych and Jyoti Chattopadhyaya).
Chapter 8 Labeling oligonucleotides towards the biomedical probe (Il Joon Lee and Byeang Hyean Kim).
Chapter 9 Locked Nucleic Acid Oligonucleotides Towards Clinical Application (Rakesh N. Veedu and Jesper Wengel).
Chapter 10 The pharmacokinetics researches of nucleic acid drugs (Shengqi Wang).
Chapter 11 Inducible RNAi and drug target validation (Wei Xiong, Jing Zhao, Yufan Zhang, Jinxi Wang, Yong-Xiang Zheng, Qiu-Chen He, Li-He Zhang, and De-Min Zhou).
Chapter 12 siRNA: The specificity and off-target effects (Quan Du, Huang Huang, and Zicai Liang).
Index.
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