SEVERE ACUTE RESPIRATORY SYNDROME

With the causative agent now identified as a new strain of coronavirus, the medical world has gained important knowledge on the aetiology, clinical presentation, diagnosis, pathogenesis, epidemiology, disease treatment and infection control with amazing speed.

Despite this, major gaps remain in our understanding - the race is on to develop new cures and effective vaccines, and the long-term impact on health, society and economics are starting to unravel.

Severe Acute Respiratory Syndrome: A Clinical Guide meets the urgent need for a comprehensive, authoritative reference guide for everyone in the medical and scientific community engaged in the fight against SARS:

• Definitive book on SARS, clearly and accurately documenting the extraordinary medical and scientific events around this new epidemic
  
• International experts in the field, with many contributors from the WHO and CDC
  
• Will help reader to understand and prevent future outbreaks with a repeat of the same consequences

Larry J Anderson, Chief, Respiratory and Enteric Viruses Branch, MS A34, Centers for Disease Control and Prevention, Atlanta, USA

Albert DME Osterhaus, Department of Virology, Erasmus Medical Centre, The Netherlands

Klaus Stohr, Global Influenza Programme, CDS/CSR, RMD, Switzerland

Kwok-yung Yuen, Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Hong Kong

Acknowledgements, xv.

1 SARS: A Historical Perspective from Hong Kong.

Kwok-yung Yuen and Nan-shan Zhong.

2 SARS: A Global Perspective.

David L Heymann.

3 Clinical Presentation of the Disease in Adults.

JY Sung and Kwok-yung Yuen.

4 SARS in Children.

CW Leung.

5 SARS: Sequelae and Implications for Rehabilitation.

David S Hui and Kenneth W Tsang.

6 Radiology of SARS.

Clara GC Ooi.

7 Aetiology of SARS.

Malik Peiris and Albert DME Osterhaus.

8 Structure of the Genome of SARS CoV.

Paul A Rota, Xin Liu, Byron T Cook and Suxiang Tong.

9 Viral Diagnosis of SARS.

C Drosten, KH Chan and LLM Poon.

10 Pathology and Pathogenesis.

JM Nicholls and T Kuiken.

11 SARS Coronavirus: An Animal Reservoir?.

Yi Guan, Hume Field, Gavin JD Smith and Honglin Chen.

12 Comparative Biology of Animal Coronaviruses: Lessons for SARS.

Linda J Saif.

13 Epidemiology and Transmission of SARS.

Angela Merianos, Robert Condon, Hitoshi Oshitani, Denise Werker and Roberta Andraghetti.

14 Transmission Dynamics and Control of the Viral Aetiological Agent of SARS.

Gabriel M Leung, Anthony J Hedley, Tai Hing Lam, Azra C Ghani, Christl A Donnelly, Christophe Fraser, Steven Riley, Neil M Ferguson and Roy M Anderson.

15 The Seasonality of Respiratory Virus Diseases: Implications for SARS?.

JC de Jong and WL Lim.

16 Public Health Response: A View from Singapore.

Chorh Chuan Tan.

17 Public Health Response: A View from Hong Kong.

T Tsang.

18 Public Health Response: A View from a Region with a Low Incidence of SARS.

James W LeDuc.

19 Infection Control for SARS: Causes of Success and Failure.

WH Seto, PTY Ching and PL Ho.

20 Antiviral Agents for SARS.

Frederick G Hayden and Mark R Denison.

21 Vaccines.

Kanta Subbarao.

22 Counting the Economic Cost of SARS.

YC Richard Wong and Alan Siu.

23 Preparing for a Possible Resurgence of SARS.

Umesh D Parashar, Angela Merianos, Cathy Roth and Larry J Anderson.

24 Lessons for the Future: Pandemic Influenza.

Robert G Webster and David S Fedson.

25 Lessons Learnt.

Albert DME Osterhaus and Malik Peiris.

Appendix.

Index.

Colour plate facing page