Biosensors and Molecular Technologies for Cancer Diagnostics

Bridging the gap between research and clinical application, Biosensors and Molecular Technologies for Cancer Diagnostics explores the use of biosensors as effective alternatives to the current standard methods in cancer diagnosis and detection. It describes the major aspects involved in detecting and diagnosing cancer as well as the basic elements of biosensors and their applications in detection and diagnostics.

The book addresses cancer molecular diagnostics, including genomic and proteomic approaches, from the perspective of biosensors and biodetection. It explains how to measure and understand molecular markers using biosensors and discusses the medical advantages of rapid and accurate cancer diagnostics. It also describes optical, electrochemical, and optomechanical biosensor technologies, with a focus on cancer analysis and the clinical utility of these technologies for cancer detection, diagnostics, prognostics, and treatment.

Making biosensor technology more accessible to molecular biologists, oncologists, pathologists, and engineers, this volume advances the integration of this technology into mainstream clinical practice. Through its in-depth coverage of a range of biosensors, the book shows how they can play instrumental roles in the early molecular diagnosis of cancer.

Keith E. Herold is an associate professor in the Fischell Department of Bioengineering at the University of Maryland. A fellow of the ASME, Dr. Herold has over 10 years of experience in the analysis and testing of biosensor systems. His current research interests include bioMEMS, microfluidic systems for bioanalytical assays, and heat and mass transfer in bioengineering.
Avraham Rasooly is the chief of the Disparities Research Branch at the National Cancer Institute and a member of the Division of Biology in the Center for Devices and Radiological Health at the U.S. Food and Drug Administration.

IntroductionCancer and the Use of Biosensors for Cancer Clinical Testing, R.F. Chuaqui, Keith E. Herold, and Avraham Rasooly

Optical Technologies for Cancer Detection and Diagnostics: Surface Plasmon ResonanceSurface Plasmon Resonance Biosensor Based on Competitive Protein Adsorption for the Prognosis of Thyroid Cancer, Seokheun Choi and Junseok ChaeSurface Plasmon Resonance Analysis of Nanoparticles for Targeted Drug Delivery, Emilie Roger, Alex E. Grill, and Jayanth PanyamDual-Functional Zwitterionic Carboxybetaine for Highly Sensitive and Specific Cancer Biomarker Detection in Complex Media Using SPR Biosensors, Norman D. Brault, Shaoyi Jiang, and Qiuming YuSurface Plasmon Resonance (SPR) and ELISA Methods for Antibody Determinations as Tools for Therapeutic Monitoring of Patients with Acute Lymphoblastic Leukemia (ALL) after Native or Pegylated Escherichia coli and Erwinia chrysanthemi Asparaginases, Vassilios I. Avramis

Optical Technologies for Cancer Detection and Diagnostics: Evanescent Wave and Waveguide BiosensorsPhotonic Biochip Sensor System for Early Detection of Ovarian Cancer, Debra Wawro, Peter Koulen, Shelby Zimmerman, Yiwu Ding, Charles Kearney, and Robert MagnussonLabel-Free Optofluidic Ring Resonator Biosensors for Sensitive Detection of Cancer Biomarkers, Hongying Zhu and Xudong FanResonant Waveguide Grating Biosensor for Cancer Signaling, Ye Fang and Ann M. FerrieOptical Waveguide-Based Biosensors for the Detection of Breast Cancer Biomarkers, Harshini Mukundan, John E. Shively, Aaron S. Anderson, Nile Hartman, W. Kevin Grace, and Basil I. SwansonLabel-Free Resonant Waveguide Grating (RWG) Biosensor Technology for Noninvasive Detection of Oncogenic Signaling Pathways in Cancer Cells, Yuhong Du, Min Qui, and Haian Fu

Optical Technologies for Cancer Detection and Diagnostics: Spectrometry for Cancer AnalysisNoninvasive and Quantitative Sensing of Tumor Physiology and Function via Steady-State Diffuse Optical Spectroscopy, Karthik Vishwanath, Gregory Palmer, Quincy Brown, and Nimmi RamanujamNoble Metal Nanoparticles as Probes for Cancer Biomarker Detection and Dynamic Distance Measurements in Plasmon Coupling Microscopy, Hongyun Wang, Guoxin Rong, Jing Wang, Bo Yan, Lynell R. Skewis, and Björn M. ReinhardCost-Effective Evaluation of Cervical Cancer Using Reflectance and Fluorescence Spectroscopy, Shabbir B. Bambot

Optical Technologies for Cancer Detection and Diagnostics: Optical Imaging for Cancer AnalysisLocation and Biomarker Characterization of Circulating Tumor Cells, H. Ben Hsieh, George Somlo, Xiaohe Liu, and Richard H. BruceHigh-Resolution Microendoscopy for Cancer Imaging, Mark C. Pierce, Veronica Leautaud, Ann Gillenwater, Sharmila Anandasabapathy, and Rebecca Richards-KortumLensless Fluorescent Imaging on a Chip: New Method toward High-Throughput Screening of Rare Cells, Ahmet F. Coskun, Ting-Wei Su, Ikbal Sencan, and Aydogan OzcanMultiphoton Luminescence from Gold Nanoparticles as a Potential Diagnostic Tool for Early Cancer Detection, Nicholas J. Durr, Marica B. Ericson, and Adela Ben-YakarEarly Detection of Oral Cancer Using Biooptical Imaging Technologies, Malini Olivo, Ramaswamy Bhuvaneswari, Kho Kiang Wei, Ivan Keogh, and Soo Khee CheeTactile Sensing and Tactile Imaging in Detection of Cancer, A. Sarvazyan, V. Egorov, and N. Sarvazyan

Optical Technologies for Cancer Detection and Diagnostics: Fluorescence, Luminescence, Refractive Index Detection TechnologiesBiomechanics-Based Microfluidic Biochip for the Effective Label-Free Isolation and Retrieval of Circulating Tumor Cells, Swee Jin Tan, Wan Teck Lim, Min-Han Tan, and Chwee Teck LimSensitive Mesofluidic Immunosensor for Detection of Circulating Breast Cancer Cells onto Antibody-Coated Long Alkylsilane Self-Assembled Monolayers, François Breton and Phuong-Lan TranMicropatterned Biosensing Surfaces for Detection of Cell-Secreted Inflammatory Signals, Jun Yan and Alexander RevzinQuantum Dots Nanosensor Analysis of Tumor Cells, Lee-Jene Lai, Yi-Heui Hsieh, and Shih-Jen LiuCompact Discs Technology for Clinical Analysis of Drugs, Ángel MaquieiraColorimetric Multiplexed Immunoassay for Sequential Detection of Tumor Markers, Jing Wang and Genxi LiMolecular Pincers for Detecting Cancer Markers, Ewa Heyduk and Tomasz HeydukFluorescent Nanoparticles for Ovarian Cancer Imaging, Xu Hun, Liang Tiao, and Zhujun ZhangDetection of Cancer-Associated Autoantibodies as Biosensors of Disease by Tumor Antigen Microarrays, Steven P. Dudas, Madhumita Chatterjee, Wei Chen, and Michael A. Tainsky

Optical Technologies for Cancer Detection and Diagnostics: Photoacoustic for Cancer AnalysisDetecting Circulating Melanoma Cells in Blood Using Photoacoustic Flowmetry, John A. Viator, Benjamin S. Goldschmidt, and Kyle D. Rood

Electrochemical BiosensorsSelf-Contained Enzymatic Microassay Biochip for Cancer Detection, Jianwei Mo, JrHung Tsai, and Brian J. SullivanElectrochemical Protein Chip for Tumor Marker Analysis, Michael S. WilsonCharacterization of Cancer Cells Using Electrical Impedance Spectroscopy, Dorielle Price, Abdur Rub Abdur Rahman, and Shekhar BhansaliElectrochemical Immunosensor for Detection of Proteic Cancer Markers, Alex Fragoso and Ciara K. O’SullivanElectrochemical Biosensors for Measurement of Genetic Biomarkers of Cancer, Robert Henkens and Celia BonaventuraMicroimpedance Measurements for Cellular Transformation and Cancer Treatments, Chang Kyoung Choi, Giljun Park, and Tim E. SparerMultiplexible Electrochemical Sensor for Salivary Cancer Biomarker Detection, Fang Wei, Wei Liao, and David T.W. WongMicroelectrode Array Analysis of Prostate Cancer, Frank Davis, Andrew C. Barton, and Séamus P.J. HigsonGraphene-Based Electrochemical Immunosensor for the Detection of Cancer Biomarker, Minghui Yang, Alireza Javadi, and Shaoqin GongLabel-Free Electrochemical Sensing of DNA Hybridization for Cancer Analysis, Venkataraman Dharuman and Jong Hoon HahnElectrochemical Biosensor for Detection of Chronic Myelogenous Leukemia and Acute Promyelocytic Leukemia, Yuanzhong Chen, Xinhua Lin, Ailin Liu, and Kun Wang

Electronic and Magnetic Technologies for Cancer AnalysisNanowire Transistor–Based DNA Methylation Detection, Wusi C. Maki, Gary K. Maki, and Niranka MishraCancer Cell Detection and Molecular Profiling Using Diagnostic Magnetic Resonance, Cesar M. Castro, Hakho Lee, and Ralph WeisslederField Effect Transistor Nanosensor for Breast Cancer Diagnostics, Pritiraj Mohanty, Yu Chen, Xihua Wang, Mi K. Hong, Carol L. Rosenberg, David T. Weaver, and Shyamsunder ErramilliMeasuring the Electric Field in Skin to Detect Malignant Lesions, Richard Nuccitelli, KaYing Lui, Kevin Tran, Brian Athos, Mark Kreis, and Pamela Nuccitelli

Thermometric SensingNext Generation Calorimetry Based on Nanohole Array Sensing, Gregory J. Kowalski, Mehmet Sen, and Dale Larson

Cantilever-Based TechnologyMicrocantilever Biosensor Array for Cancer Research: From Tumor Marker Detection to Protein Conformational State Analysis, Riccardo Castagna and Carlo Ricciardi

Index