Cancer Targeted Drug Delivery ― An Elusive Dream

This volume provides information related to the difficulties in treating cancers through targeted drug delivery. It examines our current understanding of cancer biology as well as potential technologies that may achieve enhanced drug delivery to tumors.

Professor You Han Bae

Professor You Han Bae received his Ph.D. in 1988 from University of Utah. He has background of chemical engineering and polymer science/engineering and pharmaceutical chemistry. He served University of Utah as a postdoctoral fellow and research assistant/associate professor till 1994. He joined the Department of Materials Science and Engineering at Gwangju Institute of Science and Technology (GIST) in Korea in 1994 as an associate professor and promoted to a full Professor in 1998. After serving 7.5 years at GIST, he came back to the University of Utah as a full professor in 2002.

He researched stimuli sensitive polymers and drug delivery, protein drug stabilization and controlled release, and functionalized polymers for glucose sensor and biohybrid artificial pancreas. His current research interests include nanoparticulates for multidrug resistance in cancer and tumor heterogeneity, novel carrier design for the delivery of genetic materials and preclinical cancer models. He is the author or co-author of over 240 peer-reviewed scientific papers, book chapters and U.S. Patents which have been cited more than 14,000 times.

He is an editorial board member of Pharmaceutical Research and Bioconjugate, and is also currently serving the Journal of Controlled Release (JCR) as an America Associate Editor as well as the Editor of the Concept Paper in JCR.

Professor Randall Mrsny

Professor Randall Mrsny received his Ph.D. degree in Human Anatomy and Cell Biology from the University of California at Davis in 1981 where he was an NIH predoctoral fellow. He was awarded an NIH postdoctoral fellowship that he undertook at the Institute of Molecular Biology at the University of Oregon where he focused on research in Membrane Biophysics. Professor Mrsny then joined ALZA Corporation where he led the Peptide Biology Group and then moved to Genentech where he led the Drug Delivery / Biology group. In 2000 he left Genentech to start two separated biotech companies and take a part-time Professor of Drug Delivery post at Cardiff University. In 2009 he moved to the Department of Pharmacy and Pharmacology at the University of Bath where he now holds a full-time Professor of Epithelial Biology post.

Professor Mrsny's research has focused primarily on understanding biological barriers of the body that limit or modulate the delivery of biopharmaceuticals using a multi-disciplinary approach. His current research includes the identification of vesicular trafficking pathways in epithelial hijacked cells that are by bacterial toxins, mechanism epithelial cells to regulate the transmigration of neutrophils, and protein-protein contacts involving tight junction elements that control paracellular permeability properties of epithelia. He has published more than 90 peer-reviewed papers, 25 book chapters and reviews, and presented more than 100 abstracts at national and international meetings. He co-authored and co-edited 5 books in the area of controlled drug delivery. He is the founder of Unity Pharmaceuticals and Applied Molecular Transport.

Professor Kinam Park

Professor Kinam Park received his Ph.D. degree in pharmaceutics from University of Wisconsin in 1983. After a postdoctoral training at the Department of Chemical Engineering of the same university, he joined the faculty of the Purdue University in 1986 and promoted to Full Professor of Pharmaceutics in 1994. Since 1998, he has held a joint appointment in Department of Biomedical Engineering, and became Showalter Distinguished Professor of Biomedical Engineering in 2006.