Phosphate and Vitamin D in Chronic Kidney Disease

Razzaque (oral medicine, infections, and immunity, Harvard School of Dental Medicine) compiles 11 articles that review the physiological aspects of phosphate and vitamin D metabolism and how their dysregulation affects the progression of chronic kidney disease and patient outcomes. Researchers from the US, Japan, Kuwait, Brazil, and Europe discuss the involvement of the fibroblast growth factor 23-klotho system in impaired phosphate transport, extracellular phosphate as a signaling molecule, the complex regulation and diverse functions of alpha-klotho, the klotho protein as a biomarker and therapeutic agent for chronic kidney disease, the renal and intestinal actions of the liver X receptor agonists, phosphate toxicity and vascular mineralization, vitamin D and type II sodium-dependent phosphate cotransporters, parathyroid dysfunction, and salivary phosphate levels as an early biomarker for monitoring the genesis of obesity in children. Annotation c2013 Book News, Inc., Portland, OR (booknews.com)