Rational Basis for Clinical Translation in Stroke Therapy

During the last decades, numerous promising drugs that provided neuroprotection in the laboratory setting failed to translate into the clinic because of their toxicity or lack of efficacy. However, these apparently disappointing results have provided valuable lessons to improve research strategies and enhance their clinical translation. In this scenario, by bringing together the experience developed by stroke researchers and clinicians, the book provides a precious tool for improving stroke patients’ treatment and management.

Giuseppe Micieli is director of the Department of Emergency Neurology at the IRCCS "C. Mondino" Foundation in Pavia, Italy, as well as adjunct professor at the University of Pavia. He received his degree in medicine and surgery from the University of Pavia and holds specialization degrees in neurology and clinical pharmacology. He is former director of the Laboratory of Vegetative Physiopathology, the Headache Centre, and the Sub-intensive Unit of Cerebrovascular Diseases at the IRCCS "C. Mondino" Foundation. He is also the former leader of the Emergency Neurology and Stroke Unit of the Humanitas Clinical Institute in Rozzano, Milan. Dr. Micieli has published more than 170 peer-reviewed articles and held numerous leadership positions including coordinating roles for the Stroke Unit Network and the Italian Stroke Forum.

Diana Amantea is aggregate professor of pharmacology in the Department of Pharmacy, Health Sciences and Nutrition at the University of Calabria, Italy. She also leads the Stroke Research Unit at the Center of Preclinical and Translational Pharmacology located in the University of Calabria. Dr. Amantea received her PharmD from the University of Calabria and her PhD in pharmacology from the University of Birmingham. Her research focuses on understanding the inflammatory mechanisms occurring during ischemic brain injury in order to identify novel pharmacological targets for stroke therapy.