Sudden Unexpected Death in Epilepsy ─ Mechanisms and New Methods for Analyzing Risks

This book presents a concise method for identifying and classification clusters of risks that lead to sudden death in persons with epilepsy (SUDEP). It demonstrates how medical examiners, coroner’s offices, emergency room physicians, and attending physicians can use this system of risk factor classification to detect and prevent the occurrence of SUDEP. The forensic SUDEP Syndrome Clusters enables enhanced management of persons with epilepsy since the attending physician will be able to identify those patients at a higher and highest risk for death from SUDEP.

Claire M. Lathers, PhD, FCP, has been credentialed as a senior biomedical research scientist by the FDA for international recognition of her work in the two areas of cardiovascular autonomic dysfunction associated with sudden death in persons with epilepsy and with space flight and for her professional management experience in drug development, the business world, and clinical pharmacology. The primary focus of her international cardiovascular pharmacology research career has centered on autonomic peripheral and central mechanisms involved in the control and regulation of blood pressure, heart rate and rhythm, and electroencephalogram. Dr. Lathers served as President Clinton’s lead person on the Food Safety Program at FDA, was Director of the Office of New Animal Drug Evaluation and a Senior Advisor for Science at FDA.

Paul L. Schraeder, MD, FAAN, is Professor Emeritus of Neurology at Drexel University College of Medicine. Along with Dr. Lathers, Dr. Schraeder has spent over three decades studying and investigating the mystery of SUDEP and developed the first experimental animal models of this fatal phenomenon. Dr. Schraeder organized a collaborative nationwide survey of how coroners and medical examiners evaluate the deaths of persons with a history of epilepsy.

Jan E. Leestma, MD, MBA, is licensed as a physician in the states of Illinois and Michigan and certified by the American Board of Pathology in both Anatomic Pathology and Neuropathology. His areas of expertise and publication history include sudden unexpected death in epilepsy, viral infections of the central nervous system, and forensic neuropathology.

Braxton B. Wannamaker, MD, FAAN is Clinical Professor of Neurology at the Medical University of South Carolina (MUSC). In his long career devoted to comprehensive care of persons with epilepsy, Dr. Wannamaker has served as a member of the NINDS Epilepsy Advisory Committee, as a board member of the Epilepsy Foundation of America, and as president of the American Epilepsy Society.

Richard L. Verrier, PhD, FACC, is Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts. He has investigated autonomic factors in sudden cardiac death for over 25 years in both clinical and experimental studies. He demonstrated that the phenomenon of T-wave alternans (TWA) is strongly correlated with ventricular fibrillation, the arrhythmia responsible for sudden cardiac death in patients with cardiovascular disease.

Steven C. Schachter, MD, is Professor of Neurology at Harvard Medical School; chief academic officer and director of neurotechnology for the Consortia for Improving Medicine Through Innovation and Technology in Boston, Massachusetts; and senior neurologist at Beth Israel Deaconess Medical Center, Boston. He has directed over 70 research projects involving antiepileptic therapies and published over 200 articles and chapters. He compiled the six-volumeBrainstorms series, and edited or wrote 23 other books on epilepsy and behavior.