Perinatal and Prenatal Disorders

This authoritative volume describes the role of free radicals and antioxidants in prenatal and perinatal disorders currently explored in clinical and pre-clinical trials. In twenty-two inclusive chapters, the book covers the gamut of oxidative stress and its relation to a variety of factors, including fertility, metabolism, redox biomarkers, antioxidant defense and protection, gene polymorphisms, angiogenesis, cell signaling, mutations and oxidative damage involving lipids, proteins and nucleic acids, membrane trafficking, inflammation, mitochondrial dysfunction, alterations in immunological function, hypoxia, and post-natal stressors. This comprehensive source will keep clinicians and research scientists up-to-date on translational research into medical applications.Perinatal and Prenatal Disorders is a significant addition to the well-knownOxidative Stress in Applied Basic Research and Clinical Practice series.

Phyllis A. Dennery, MD, FAAP is a professor of pediatrics at the University of Pennsylvania School of Medicine in Philadelphia, Pennsylvania. She holds the Werner and Gertrude Henle endowed chair in pediatrics at The Children’s Hospital of Philadelphia (CHOP). She is chief of the Division of Neonatology and Newborn Services at CHOP and the University of Pennsylvania Health System. Dr. Dennery obtained her medical degree from Howard University in Washington, D.C., and completed a residency in pediatrics at Children’s Hospital National Medical Center in Washington, D.C., and a fellowship in neonatology at Case Western Reserve University (Rainbow Babies and Children’s Hospital) in Cleveland, Ohio. Dr. Dennery’s research interests are in neonatal oxidative stress, lung chronobiology, and circadian gene regulation; her clinical interests are in neonatal jaundice, bronchopulmonary dysplasia, and the long-term consequences of prematurity.

Professor Giuseppe Buonocore is professor and chairman of the School of Specialization in Pediatrics & Neonatology in the Department of Molecular and Developmental Medicine, University of Siena, Tuscany. He is internationally recognized for his research on hyperbilirubinemia, biomarkers of oxidative stress, free radical–related diseases of the newborn, and the early identification of the fetus and newborn at high risk of brain damage. He is the president of the Union of European Neonatal Perinatal Societies (UENPS), president of the international research foundation Europe Against Infant Brain Injury (EURAIBI), and president of the Tuscan Section of the Italian Society of Neonatology.

Dr. Ola Didrik Saugstad is professor of pediatrics, and director of research in the Department of Pediatrics at the University of Oslo in Norway. He is a consultant of neonatology at Oslo University Hospital, Rikshospitalet. Dr. Saugstad obtained his MD and PhD from University of Oslo. He completed research fellowships in neonatology from the University of Oslo and the University of Uppsala in Sweden, and he carried out a postdoctoral fellowship from the University of California San Diego. His main research interests are asphyxia, oxidative stress in premature infants, reoxygenation, and resuscitation of newborn infants. He holds an Honorary Doctorate from the University of Athens in Greece and is a member of several editorial boards of pediatric and perinatal journals.