Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy ― New Perspectives and Opportunities

Apoptosis, the most widely studied mode of programmed cell death, is well known for its tumor-suppressive properties: deletion of mutated cells through activation of apoptosis and induction of the process by anti-cancer therapies are amongst its intuitively important properties. Less obvious are the emerging functions of apoptosis in promoting progression or post-therapeutic relapse of malignant disease. This book provides a series of reviews that discuss these "yin and yang" properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. From modulation of anti-tumor inflammatory and immune responses, through consideration of its effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, this book places the onco-biology of apoptosis in clear and objective perspective. It will appeal to apoptosis aficionados, cancer experts and students alike, highlighting an area that will undoubtedly grow rapidly over the forthcoming years.

Christopher D. Gregory is Professor of Inflammatory Cell Biology and the Deputy Director of the MRC Centre for Inflammation Research at the University of Edinburgh. Dr. Gregory is an active research group leader in the fields of immunology, inflammation, and cancer with a particular interest in apoptosis. He has published 95 scientific papers and has received over 6,950 citations.