Nanoemulsion and Nanoemulsion Gel: A Novel Drug Delivery System
商品資訊
ISBN13:9781636484631
出版社:Lightning Source Inc
作者:Satyabrata Bhanja
出版日:2021/12/24
裝訂:平裝
規格:22.9cm*15.2cm*0.4cm (高/寬/厚)
定價
:NT$ 1700 元無庫存,下單後進貨(到貨天數約30-45天)
下單可得紅利積點:51 點
相關商品
商品簡介
商品簡介
The current research work in all technical and biomedical fields is based on nanosize. Nanoemulsions are defined as transparent dispersions of oil and water stabilized as an interfacial film of surfactant and co-surfactant molecules having droplet size less than a micron. Nanoemulsions are thermodynamically stable dispersed system. Nanoemulsions were previously proved to be potential drug delivery tool for ocular, pulmonary, nasal, vaginal, and parental. In recent times, they have shown promising potential as transdermal drug delivery in delivering drug across the skin than other conventional transdermal delivery system. Nanoemulsions can be prepared by high-pressure homogenization, microfludization, ultrasonication and phase inversion method.Incorporating the preparation of nanoemulsion with hydrogel matrix to produce nanoemulgel exhibited by the two separate systems that forming it. Nanoemulgel possesses the properties of thixotropic, non-greasy, effortlessly spreadable, easily be removed, emollient, not staining, soluble in water, longer shelf life, bio-friendly, translucent and agreeable appearance. To enhance the solubility and permeability of poorly water soluble Valdecoxib, Nanoemulsion gel was formulated for the treatment of rheumatoid arthritis. Among the oils, surfactants and co-surfactants elainic acid, tween80 and ethanol were selected as they showed maximum solubility to Valdecoxib. The pseudo ternary phase-diagrams was constructed to find optimal concentration that provided the highest drug loading. The prepared Nanoemulsions were subjected trough thermodynamic stability testing.The droplet size, scanning electron microscopy (SEM) and zeta-potential were investigated.The optimized formulation of Nanoemusion NE2 which was showing 87.63% drug release was incorporated into polymeric gel of Carbopol940 for convenient application and evaluated for viscosity, PH, in-vitro permeations studies, skin irritation test and anti-inflammatory activity. The in-vitro skin permeations profile of optimized formulation was compared with normal Valdecoxib gel and Nanoemulsiongel NG2.The significant increase in permeability ratio (Kp), flux (Jss) and enhancement ratio (Er) was observed.The anti-inflammatory effect of formulation NG2 showed significant increase 72% inhibition effect in 24hrs when compared to Valdecoxib gel on Carrgeenan induced paw edema in rats. The results suggested that Nanoemulsion gels are potential vehicles for improved transdermal delivery of Valdecoxib.
主題書展
更多
主題書展
更多書展本週66折
您曾經瀏覽過的商品
購物須知
外文書商品之書封,為出版社提供之樣本。實際出貨商品,以出版社所提供之現有版本為主。部份書籍,因出版社供應狀況特殊,匯率將依實際狀況做調整。
無庫存之商品,在您完成訂單程序之後,將以空運的方式為你下單調貨。為了縮短等待的時間,建議您將外文書與其他商品分開下單,以獲得最快的取貨速度,平均調貨時間為1~2個月。
為了保護您的權益,「三民網路書店」提供會員七日商品鑑賞期(收到商品為起始日)。
若要辦理退貨,請在商品鑑賞期內寄回,且商品必須是全新狀態與完整包裝(商品、附件、發票、隨貨贈品等)否則恕不接受退貨。