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Cryoelectron microscopy of biological molecules is among the hottest growth areas in biophysics and structural biology at present, and Frank is arguably the most distinguished practitioner of this ar

Cryoelectron microscopy of biological molecules is among the hottest growth areas in biophysics and structural biology at present, and Frank is arguably the most distinguished practitioner of this art

The concept of molecular machines in biology has transformed the medical field in a profound way. Many essential processes that occur in the cell, including transcription, translation, protein folding and protein degradation, are all carried out by molecular machines. This volume focuses on important molecular machines whose architecture is known and whose functional principles have been established by tools of biophysical imaging (X-ray crystallography and cryo-electron microscopy) and fluorescence probing (single-molecule FRET). This edited volume includes contributions from prominent scientists and researchers who understand and have explored the structure and functions of these machines. This book is essential for students and professionals in the medical field who want to learn more about molecular machines.

The book reproduces 55 of more than 300 articles written by the author, representing milestones in methods development of single-particle cryo-EM as well as important results obtained by this techniqu

This definitive work provides a comprehensive treatment of the mathematical background and working methods of three-dimensional reconstruction from tilt series. Special emphasis is placed on the probl

The aim of this book is to make available, to students and experts, a compendium of important articles covering the development of single-particle reconstruction techniques, and the progress in the ex

This definitive work provides a comprehensive treatment of the mathematical background and working methods of three-dimensional reconstruction from tilt series. Special emphasis is placed on the probl

Approaches to the recovery of three-dimensional information on a biological object, which are often formulated or implemented initially in an intuitive way, are concisely described here based on physi

Here, renowned researchers in bioanalysis present in-depth reviews of recent trends in the field. Coverage includes topics such as aptamers, bioelectroanalysis, nanoparticles, quantitative NMR, mass s

Traditionally, stretched paper, finely-cut stone, or stained glass were used to create mood and atmosphere. These are now giving way to a new generation of innovative materials - composite glass, synt

An intimate art form, drawing offers a direct connection to one's imagination; a means of exercising the eye, brain, and the hand; and a way to spark new ideas and resolve pictorial challenges. This v

This book provides a complete introduction to both the practical details and the theoretical foundations required in order to use electron microscopy as a research tool in structural biology. Planned