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Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition,provides an update on major achievements in the translation of research into medically relevant results and thera

Despite advancements in the cloning of the human genome, biomedical innovations at patient level are rare events. Translational medicine is, however, a burgeoning science that shows potential to reverse the trend. This textbook provides a survey of translational medicine, emphasising its emerging scientific backbone, its strengths and weaknesses. It explores all aspects of preclinical and clinical issues relevant to the success of translational pharmaceutical or medical device or diagnostic innovations, including target risk assessment, biomarker evaluation, and predictivity grading for both efficacy and toxicity; early human trial designs, adequate to guide stop or go decisions on the grounds of biomarker panels; and biostatistical methods to analyze multiple readout situations and quantify risk projections. Translational Science in Medicine provides guidance to design profiling strategies for new approaches to the field. By generating dialogue about translational science Wehling

While the writing of Carlo Emilio Gadda (1893-1973) is renowned for its linguistic and narrative proliferation, the best-known works of Samuel Beckett (1906-89) are minimalist, with a clear fondness f

At first glance, issues like economic inequality, healthcare, climate change, and abortion seem unrelated. However, when thinking and talking about them, people reliably fall into two camps: conservat

“The essential handbook for thinking and talking Democratic—must reading not only for every Democrat but for every responsible citizen” (Robert B. Reich, former Secretary of Labor and author of Beyond

With people aged 65 years and older currently making up the fastest growing age group throughout the world, the demographic revolution of an aging society will inevitably lead to increased pressure to

READINGS IN WORLD POLITICS covers the history, economics, issues, and theory of world politics. Through a series of articles and essays, you will explore theory and aplications in the intriguing fiel

Patient organizations and social health movements offer one of the most important and illuminating examples of civil society engagement and participation in scientific research and research politics.

This is the first edited volume in English on the Sicilian author Goliarda Sapienza, contextualizing her work within Italian and European literature. The essays in this volume examine Sapienza through