Acute liver failure (ALF), or fulminant hepatic failure, is a distinct clinical syndrome which crosses medical disciplines. A relatively rare condition, ALF remains a major focus of clinical and research attention and with the advent of transplantation, the importance of understanding management of ALF has taken on a new urgency. In this 1997 volume, the editors bring together a distinguished team of contributors to describe the aetiology, pathology and treatment of this important syndrome. Also covered are consensus techniques in liver transplantation for ALF patients, as well as descriptions of artificial and bioartificial liver assist devices. A section on future treatments includes hepatocyte transplantation, auxiliary grafts and other temporary liver support. Notable for the high level of authors' expertise, this comprehensive volume should prove invaluable to internists, gastroenterologists, surgeons, and intensive care providers.
The thesis of this innovative and challenging book, first published in 2001, is that brain drug development has been restricted by the failure of adequate brain drug targeting, and that this is an increasingly urgent problem as developments in genomics lead to new generations of therapeutic macromolecules. The author, a world leader in the study of the blood-brain barrier and its clinical implications, reviews the field of neurotherapeutics from the point of view of drug targeting. He surveys the scientific and clinical basis of drug delivery across biological membranes, including topics such as genetically engineered trojan horses for drug targeting, antisense neurotherapeutics, and gene therapy of brain disorders. At a time when there are few significant new drug treatments in prospect for common neurological diseases, this authoritative review will encourage a wide range of clinicians and neuroscientists to reexamine the development and use of drugs in treating disorders of the cent
Acute liver failure (ALF), or fulminant hepatic failure, is a distinct clinical syndrome which crosses medical disciplines. A relatively rare condition, ALF remains a major focus of clinical and research attention and with the advent of transplantation, the importance of understanding management of ALF has taken on a new urgency. In this 1997 volume, the editors bring together a distinguished team of contributors to describe the aetiology, pathology and treatment of this important syndrome. Also covered are consensus techniques in liver transplantation for ALF patients, as well as descriptions of artificial and bioartificial liver assist devices. A section on future treatments includes hepatocyte transplantation, auxiliary grafts and other temporary liver support. Notable for the high level of authors' expertise, this comprehensive volume should prove invaluable to internists, gastroenterologists, surgeons, and intensive care providers.
The blood-brain barrier serves to protect the brain from toxic substances whilst simultaneously allowing access to essential nutrients and chemical signals. At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. Nevertheless, it seems that ignorance of both the biology of this important membrane and the methodology suitable for its investigation still remains an impediment to progress in many fields, including, for example, the development of new and efficacious neuropharmaceuticals, cerebrovascular disease, Alzheimer's disease, cerebral AIDS and brain tumours. This introduction for both researchers and clinicians across the medical sciences is intended to aid both those beginning work directly in this area and those wishing simply to be better informed when interpreting information where the blood-brain barrier may be involved. Advances in both methodology an
What is the real nature of substantive conflict in mass politics during the postwar years in the United States? How is it reflected in the American public mind? And how does this issue structure shape electoral conflict? William J. M. Claggett and Byron E. Shafer answer by developing measures of public preference in four great policy realms - social welfare, international relations, civil rights, and cultural values - for the entire period between 1952 and 2004. They use these to identify the issues that were moving the voting public at various points in time, while revealing the way in which public preferences shaped the structure of electoral politics. What results is the restoration of policy substance to the center of mass politics in the United States.
“Phelps is the Harlan Coben of real-life thrillers.” —Allison Brennan Iowa housewife Tracey Pittman Roberts seemed to have it all: natural beauty, three loving children, and a fairy tale second marr
Relates the story of the murder of sex criminal by two of his teen-girl victims, who subsequently went on a cross-country road trip after shooting him execution-style. Original.
The Smoke of London uncovers the origins of urban air pollution, two centuries before the industrial revolution. By 1600, London was a fossil-fuelled city, its high-sulfur coal a basic necessity for the poor and a source of cheap energy for its growing manufacturing sector. The resulting smoke was found ugly and dangerous throughout the seventeenth and eighteenth centuries, leading to challenges in court, suppression by the crown, doctors' attempts to understand the nature of good air, increasing suburbanization, and changing representations of urban life in poetry and on the London stage. Neither a celebratory account of proto-environmentalism nor a declensionist narrative of degradation, The Smoke of London recovers the seriousness of pre-modern environmental concerns even as it explains their limits and failures. Ultimately, Londoners learned to live with their dirty air, an accommodation that reframes the modern process of urbanization and industrial pollution, both in Britain and
New Jersey-based utility intellectual Robins has constructed an annotated bibliography of American novelist, short story writer, and playwright Elkin (1930-95). His introductory matter includes a chro
After her mother's untimely death, Clara Schwartz became distant, withdrawn. Her father, a renowned DNA researcher, lived in a farmhouse outside Leesburg, Virginia, where in December 2001, he was fata
Medical malpractice lawsuits are common and controversial in the United States. Since early 2002, doctors' insurance premiums for malpractice coverage have soared. As Congress and state governments debate laws intended to stabilize the cost of insurance, doctors continue to blame lawyers and lawyers continue to blame doctors and insurance companies. This book, which is the capstone of three years' comprehensive research funded by The Pew Charitable Trusts, goes well beyond the conventional debate over tort reform and connects medical liability to broader trends and goals in American health policy. Contributions from leading figures in health law and policy marshal the best available information, present new empirical evidence, and offer cutting-edge analysis of potential reforms involving patient safety, liability insurance and tort litigation.
The blood-brain barrier serves to protect the brain from toxic substances whilst simultaneously allowing access to essential nutrients and chemical signals. At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. Nevertheless, it seems that ignorance of both the biology of this important membrane and the methodology suitable for its investigation still remains an impediment to progress in many fields, including, for example, the development of new and efficacious neuropharmaceuticals, cerebrovascular disease, Alzheimer's disease, cerebral AIDS and brain tumours. This introduction for both researchers and clinicians across the medical sciences is intended to aid both those beginning work directly in this area and those wishing simply to be better informed when interpreting information where the blood-brain barrier may be involved. Advances in both methodology an
Many believe the American Revolution ended in October 1781, after Lord Cornwallis surrendered his British army at Yorktown. In fact, the war effectively continued for two more traumatic years. During
Of "Good Laws" and "Good Men" reveals how a Quaker minority in the Delaware Valley used the law to its own advantage yet maintained the legitimacy of its rule.William Offutt, Jr., places legal process
From the author who brought you the shocking true story that inspired Arsenic and Old Lace comes the horrific legacy of death and destruction in the gunmaking Colt family during the 19th Century, a le
Following the flight of one woman's factory job from the United States to Mexico, this compelling work offers a revealing and unprecedented look at the flesh-and-blood consequences of globalization.In
The Hiccup Girl—From Media Darling to Convicted Killer“Phelps is a true-crime veteran.”—New York Post“Phelps is the Harlan Coben of real-life thrillers.” —Allison BrennanWhen she was 15, Jennifer Mee
The first biography in nearly a century of the legendary Revolutionary War patriot and our country’s first spy.Few Americans know much more about Nathan Hale than his famous last words: “
From the author who brought you the shocking true story that inspired "Arsenic and Old Lace" comes the horrific legacy of death and destruction in the gunmaking Colt family during the 19th Century, a
