An Evolving Paradigm: Integrative Perspectives on Orgainizational Design, Change, Strategic Management, and Ethics-was prepared specifically for Benedictine University'sdoctoral program in organizatio
An Evolving Concept in Medicinal Chemistry. Find out why unselective drugs outperform ones that are too selective Aiming broadly is the new paradigm for drug development in most major diseases.
Combining philosophy with practical politics, an expanding area of policy studies applies moral precepts, critical principles, and conventional values to collective decisions. This evolving new
This book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?
Rapid advances in neural imaging, particularly in regard to neural plasticity and brain changes, have resulted in an evolving neurorehabilitation paradigm for aphasia and related language disorders. A
Drawing on a post-foundational approach to Deleuze and Guattari’s seminal work on assemblage theory, this book explores the scholarly field of comparative and international education (CIE). Written by a diverse collection of international scholars from Australia, Ireland, Italy, Malaysia, South Africa, Sweden, Switzerland, the UK and the USA, the chapters use the assemblage paradigm as an analytical tool to examine the continuously evolving field of CIE. The theoretical chapters unpack assemblage theory and its core components, whilst others draw on examples and international case studies to show how assemblage theory could be applied to future CIE research. The field of CIE is prone to constant (re)configurations and this book casts the shaping of the field in a fresh light, prompting new discussions on the field’s variability and flexibility.
This book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?
