Molecular Mechanisms of Angiogenesis ― From Ontogenesis to Oncogenesis

Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells,…) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable bloodproof neovessels.

This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization.

The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society.

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Dr Jean-Jacques Feige is the president of the French society of angiogenesis and director of the INSERM (National institute for health and medical research) department in Grenoble, France. Dr Gilles Pages, Phd, is deputy President of the French society of angiogenesis and runs an Inserm departement at the Institute of research for Cancer and Aging in Centre Lacassagne of Nice. Dr Fabrice Soncin is the former President of the French society of angiogenesis and is a scientist at the Lille Biology institute in Lille (INSERM). Most of the contributors are prominent members of the French society of angiogenesis or international researchers who actively contribute to the Annual Meetings of the French Society of angiogenesis.